Electrical energy requirements for ventricular defibrillation.

Electrical energy requirements for ventricular defibrillation.

LABORATORY INVESTIGATION VENTRICULAR FIBRILLATION Effects of encainide and its metabolites on energy requirements for defibrillation

Encainide, a class IC antiarrhythmic agent, has been associated with proarrhythmic responses of ventricular tachycardia and fibrillation requiring defibrillation in patients. We examined the short-term effects of intravenous encainide and its two major metabolites, O-demethyl-encainide (ODE) and 3-methoxy-ODE (MODE), on the energy requirements for successful defibrillation in 25 pentobarbital-a...

Scaling Current and Energy with Body Weight: Requirements for the Transthoracic Ventricular Defibrillation of Calves

To test the hypothesis that the effectiveness of a shock in achieving ventricular defibrillation is relatively independent of body weight if electrode diameter is proportional to the one-third power and current is proportional to the two-thirds power of weight, we studied defibrillation rates in 10 calves as they increased in weight. At 50 kg, each calf was subjected to 20 fibrillation-defibril...

Impact of myocardial ischemia and reperfusion on ventricular defibrillation patterns, energy requirements, and detection of recovery.

BACKGROUND Shocks that have defibrillated spontaneous ventricular fibrillation (VF) during acute ischemia or reperfusion may seem to have failed if VF recurs before the ECG amplifier recovers after shock. This could explain why the defibrillation threshold (DFT) for spontaneous VF appears markedly higher than for electrically induced VF. METHODS AND RESULTS The DFT for electrically induced VF...

Tedisamil increases coherence during ventricular fibrillation and decreases defibrillation energy requirements.

INTRODUCTION Drugs which primarily prolong cardiac refractoriness decrease defibrillation voltage and energy requirements in animals and man. The effect of such drugs on ventricular fibrillation itself is not well understood. We hypothesized that tedisamil, an investigational antiarrhythmic drug which blocks Ito and IK repolarizing potassium channels, would increase organization of epicardial e...